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Antioxidant - Leucoselect® Grape Seed Extract 50 mg Veg Tabs (120 Count)

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Stock Number :AOX-320-VT-120
  • Heart Health – Cardiovascular Support
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  • Quick Notes:

    • Grape Seed Extract is a potent source of antioxidants termed, proanthocyanidins (OPCs).
    • This formula contains Leucoselect®..

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    List Price: $33.35

    Price: $19.98


    Product Information

    Quick Notes:

    • Grape Seed Extract is a potent source of antioxidants termed, proanthocyanidins (OPCs).
    • This formula contains Leucoselect®, a premium quality grape seed extract providing a rich source of biologically active flavonoids, including oligomeric proanthocyanidins (OPC's). Standardized to 50 mg of polyphenols to ensure consistent antioxidant potency!
    • New broad spectrum formula includes polyphenols from Green Tea Extract and Lemon Bioflavonoids!
    • Contains Green Tea Extract, which compares to approximately 1/2 to 1/3 cup of green tea in its content of EGCG (epigallocatechin gallate), the most biologically active catechin in green tea.
    • Contains only 3 mg caffeine per tablet compared to 120-240 mg in a cup of coffee.
    • Supports cells and tissues health.
    • Protects against damage from free radicals.


    Grape Seed Extract is a robust formula comprised of powerful cell protectors known as antioxidants. Grape Seed Extract contains several botanical sourced flavonoids with potent antioxidant properties including: Green Tea Extract, Grape Seed Extract and Bioflavonoids. It is important to take antioxidants in combination because they work synergistically and are more beneficial together than when taken alone.

    Grape Seed Extract:

    Grape Seed Extract is derived from tiny seeds of red grapes. It is a rich source of flavonoids which are powerful antioxidants that protect cells from free radical damage. Grape Seed Extract contains procyandolic oligomers (PCOs), also known as proanthocyanidins.

    Grape Seed Extract is considered for its potentially positive influence on blood vessels. Subsequently, PCOs are applied in Western Europe as key pharmaceuticals ingredient for vascular disorders. Grape Seed Extract exhibits great solubility in both water and fat regions of the body; therefore can penetrate more regions to deliver its potent antioxidant protection. It is also one of the few antioxidants that can cross the blood brain barrier, potentially helping to protect brain cells from free radical damage.

    Green Tea:

    Green tea contains several compounds that have antioxidant properties. The active constituents are the polyphenols called catechins and tannins. The catechin epigallocatechin gallate (EGCG) may be a much more potent antioxidant than Vitamin C and E.

    Research indicates:

      • Acts as powerful antioxidants that protect cells from free radical damage
      • May inhibit the destruction of collagen structures
      • Studies indicate people with various circulation problems in their extremities have benefited from Grape Seed Extract.
      • May support cardiovascular health
      • Studies show that Grape Seed Extract may also have the ability to block platelet activating factor (PAF), thus lengthening the time it takes for the blood to form clots
      • May support healthy inflammatory response
      • May support healthy immune function
      • Research indicates Grape Seed Extract may be of benefit in individuals with vision disorders
      • May protect the body against the damaging effects of radiation therapy and certain types of chemotherapy
      • Studies indicate Grape Seed Extract may help reduce eyestrain


    Grape Seed Extract

    Lemon Bioflavonoid complex




    Suggested Use: Take one tablet up to twice daily with food.

    Storage: Keep in a cool, dry place.

    Allergy Warnings: This product is contraindicated for individuals with hypersensitivity to any of its ingredients.


    • Everyone has unique body chemistry. All patients should be aware of potential drug and supplement interaction. You are encouraged to consult with your primary health care professional before taking any supplement product.

    • There are no known reports of toxicity associated with Grape Seed Extract.

    • If you have a bleeding disorder or are planning to have any type of surgery or dental work, stop using Grape Seed Extract for at least 14 days prior to the procedure.

    Pregnancy Warning:

    If you are pregnant, nursing, have any health condition, or are taking any medications please consult with your health care practitioner before using this product.

    Keep out of reach of children.


    • The following scientific literature references, articles, and statements have not been evaluated by the Food and Drug Administration (FDA).
    • This product is not intended to treat, cure or prevent any disease.
    • Information about this product is intended for your general knowledge only and is not a substitute for professional medical advice or treatment.
    1. Steigerwalt R, Belcaro G, Cesarone MR, et al. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. J Ocul Pharmacol Ther. 2009;25(6):537-540.

    2. Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009;26(5):526-531.

    3. Ryan J, Croft K, Mori T, et al. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. 2008;22(5):553-562.

    4. Vogels N, Nijs IM, Westerterp-Plantenga MS. The effect of grape-seed extract on 24 h energy intake in humans. Eur J Clin Nutr. 2004;58:667-673.

    5. Durackova Z, Trebaticky B, Novotny V, et al. Lipid metabolism and erectile function improvement by pycnogenol extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction—a pilot study. Nutr Res. 2003;23:1189-1198.

    6. Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7:383-388.

     7. Bagchi D, Garg A, Krohn RL, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol. 1997;95:179-189.

    8. Maffei Facino R, Carini M, Aldini G, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994;44:592-601.

    9. Kuttan R, Donnelly PV, Di Ferrante N. Collagen treated with (+)-catechin becomes resistant to the action of mammalian collagenase. Experientia. 1981;37:221-223.

    10. Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers [in French; English abstract]. Acta Ther. 1981;7:101-105.


    Frequently Asked Questions - Antioxidants & Health Aging

    • What are free radicals and antioxidants?

      Antioxidants provide the body with protection from potentially damaging compounds called free radicals. Free radicals are highly reactive chemicals with unpaired electrons that steal electrons from other molecules, causing a vicious chain reaction that wreaks havoc on the body. Free radicals can damage the body’s tissues and may increase the risk of negative health issues. 

      Free radicals are normal by-products of metabolism, normal physiological processes, as well as environmental toxins like air pollution, ozone, chemicals, drugs, cigarette smoke, radiation, heavy metals, pesticides, and especially in defense against microbes and other foreign substances. 

      Antioxidants provide preventive care to the body, protecting against the negative health consequences that can result from free radical damage. They scavenge or neutralize free radicals, stopping the free radical chain. Antioxidants can be found in a variety of foods, with higher amounts in plant foods. Many supplements are available on the market to help ensure the body receives an adequate amount of antioxidants daily. 

      Some of these traditional antioxidants include:

      • Natural vitamin E (d-alpha tocopherol)

      • Vitamin C

      • Beta-Carotene (provitamin)

      • Selenium

      Antioxidants that are available through the diet are considered exogenous antioxidants and include: amino acids [N-acetyl-L-cysteine (NAC), taurine and L-glutathione (tripeptide)], vitamins C and E, carotenoids (beta-carotene, lycopene, lutein and zeaxanthin), and minerals (selenium and zinc).  Antioxidants produced in the body are considered endogenous antioxidants and include: ubiquinone/ubiquinol (CoQ10), alpha lipoic acid, the master cellular defense enzyme, superoxide dismutase (SOD), and many more.

      However, many factors have been found to compromise the levels of endogenous antioxidants in the body making supplementation essential (for example: normal aging process, certain medications and oxidative stress).

    • What does neutralizing "free radicals" in the body mean?

      Free radicals are highly reactive compounds produced spontaneously in the body or because of exposure to certain pollutants. They can be dangerous, since they cause damage to body cells and tissues, including genetic material. Recent studies indicate that vitamins C, E, beta-carotene, and several other products characterized as antioxidants protect against free radical damage hence the term neutralizing free radicals. 

    • How much caffeine is in Advanced Antioxidant Complex?

      There is less than 1.5 mg caffeine per vegetarian capsule. Comparatively, one cup of tea provides about 50 mg of caffeine per cup.

    • Is the Alpha-Lipoic Acid in the “R” form?

      The Alpha-Lipoic Acid is 50% R form and 50% S form.

    • What is the source of Alpha-Lipoic Acid?

      The Alpha-Lipoic Acid is synthetically made, but nature identical. 

    • Why don’t you use the pure R form of Alpha- Lipoic Acid (ALA)?

      Some ALA products are in the “R” form (natural) and some are in the “S” form. The S form is an isomer, or mirror image. Our Alpha-Lipoic Acids are an equal mix (racemic mix) of both R and S. Some references claim that the R is more potent; however studies done using ALA showing benefit to blood sugar, etc. use the racemic mix. According to the PDR for Nutritional Supplements, 2001, “the natural R-enantiomer is more readily absorbed than the L-enantiomer and is the more active form...some studies showing significant antioxidant effects have used doses of the racemic mixture of 600 mg daily.” At this time, there isn’t a significant volume of human studies using the pure R form against the S form (although a few animal and in vitro ones exist) to make valuable conclusions for human dosage.

    • Alpha lipoic acid, are there two kinds?

      Alpha lipoic acid or thioctic acid is a natural antioxidant that has gained substantial attention from the scientific community for its involvement in energy production (formation of adenosine triphosphate – ATP) from the metabolism of fats, carbohydrates and proteins. Like most compounds in the body, lipoic acid has an asymmetrical carbon atom, which produces a mirror image and exists in nature as two forms (enantiomers). The forms are designated as either R or S depending on their structural relationship to a right- or left-handed reference point. While both forms are found in biological systems, lipoic acid is represented as the R-form when active. Alpha Lipoic Acid is a 50/50 mixture of both the R- and S- forms of the molecule.  Our formula provides Alpha Lipoic Acid is 50% R form and 50% S form.

    • What is Coenzyme Q10 (also called ubiquinone or ubiquinol) and how does it function in the body?

      CoQ10 is synthesized in every cell of the body. It is naturally present in small amounts in foods, but is particularly high in organ meats such as heart, liver and kidney and levels decline with age.

      To consume just 30 mg of CoQ10, you would have to eat one of the following:

      • 1 pound sardines

      • 2 pounds of beef

      • 2.5 pounds of peanuts 

    • What is the source of CoQ10?

      It is a fermentation product from yeast. This process ferments glucose and inorganic acid on bacteria.

    • What gives CoQ10 products their orange color?

      That is the natural color of CoQ10. No food coloring or other ingredients are added.

    • How and when should I take CoQ10?

      CoQ10 works better if taken with fats and oils. All forms of CoQ10 will work better if taken with a meal containing fats, or with healthy supplements providing fat, such as fish oil, flax oil, coconut oil, etc.

    • How can you determine how much CoQ10 to take?

      CoQ10 levels are concentrated in certain tissues such as the heart and muscles that use it, so you would have to do a biopsy of that tissue (not a good idea) to determine CoQ10 levels in the body. Scientific studies use certain doses in human subjects to determine effectiveness for a given condition. This is the best way to ascertain how much to take — once approved by your healthcare practitioner, of course.

    • Are there any interactions with CoQ10 and Coumadin (warfarin)?

      According to the PDR (Physician’s Desk Reference) for Nutritional Supplements, 2001, there is one report of CoQ10 decreasing the effectiveness of warfarin (Coumadin).

    • What is the difference between ubiquinol vs. ubiquinone?

      Our CoQ10 products are in the ubiquinone form. Ubiquinol is a form also found in the body — a stabilized form was launched in 2006 by a Japanese company for use in dietary supplements. A few studies show enhanced absorption with ubiquinol in the first 24 hours, but after more than one day the plasma levels achieved are identical between the two forms. 

      Ubiquinone (CoQ10) has significant antioxidant activity in the membrane portion of the mitochondria in the cell. Ubiquinone is reduced to ubiquinol (active form) as a normal process in the mitochondria to fight against the free radicals. Ubiquinone is effective in antioxidant capability and has over 30 years of research in various disease states.

    • How much caffeine does Leucoselect® Grape Seed Extract contain per tablet?

      Each tablet contains only approximately 1.5 mg of caffeine. By comparison, a single cup of coffee contains 120-240 mg.

    • What plant species is used for Leucoselect® Grape Seed Extract?

      The grape seeds come from Chardonnay grapes (Vitis vinifera) grown in France.

    • What are the components in the antioxidant Pycnogenol® and from where are they obtained?

      Pycnogenol® is a potent antioxidant (free radical scavenger) that is extracted from the bark of a specific variety of pine that grows in Southern France. It contains over 40 water soluble antioxidants and is composed primarily of proanthocyanin, a subclass of antioxidants.


      As determined by the Porter Method, the most accurate methodology available to specifically quantify proanthocyanidincontent, Pycnogenol® yields:

      • 3% water

      • 15% catechin and epicatechin (monomers)

      • 17% organic acids, organic acid glucosides and glucose esters

      • 65% proanthocyanidins

    • How many glasses of red wine would you have to drink in order to get 150 mg of resveratrol — the amount in your Resveratrol 150 mg?

      To get 150 mg of Resveratrol, you’d have to drink 79-500 (5-oz) glasses of red wine. That’s equivalent to about 15-100 bottles of red wine (assuming there is 25 floz in a bottle of wine). Please drink responsibly! 

    • What is the difference between trans-form versus cis form in Resveratrol 150 mg?

      The trans-form exists in grapes and peanuts. The cis form is created once you heat or irradiate the substance. The structural formula changes to a different arrangement of atoms but it is the same molecular formula.

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